CAR-T Therapy: A Burgeoning New Cancer Treatment

Natan Kraitman, MD
Friday, May 24, 2019
Category: Immunocompromised Host, Infectious in Oncology

Dr. Kraitman reviews the chronology of cancer treatment history, beginning with the dawn of cancer surgery and progressing through radiation, chemotherapy, immunotherapy, and ultimately, gene therapy. He then explains the basics of Chimeric Antigen Recepter T Cell therapy, a new state of the art therapy utilizing targeted T cells to destroy specific cancer cells. Dr. Kraitman then discusses potential toxicities of CART therapy, including neurotoxicty, Cytokine release syndrome, and HLH, and approaches to manage these adverse effects. Lastly, the speaker discusses infections associated with CAR-T therapy, including bacterial, fungal, and viral pathogens from a clinical series.

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