Dr. John Greene, Chief of Infectious Diseases at Moffitt Cancer Center and Research Institute, shares a photo review of Zoonosis syndromes. Topics presented include tick-borne infections, Bartonellosis, Louse-borne infections, Rickettsioses (Rocky Mountain Spotted Fever, Rickettsial pox, etc), Coxiella, Ehrlichia, and Relapsing Fever. Dr. Greene concludes the talk by covering Tularemia, the Plague (Yersinia Pestis), Orf, and the non-venereal Treponematoses.
Dr Jaela Fredenrich, ID Clinical Pharmacist at the James A Haley Veterans Hospital in Tampa, FL, discusses the differences that a clinician encounters when dosing antibiotic agents for patients with higher than average BMI values. She begins by describing the reasons why obese patients require special antibiotic dosing, and how the average weight of the typical U.S. adult has changed in the past several decades, making more patients fall into this category. Next, she discusses the specifics of the AUC/MIC concentration-time curve as it applies to aminoglycosides, vancomycin and beta lactams. The differences in volume of distribution for various classes of antibiotics is discussed next. Weight based versus fixed dosing for different antibiotic classes is also covered. Lastly the best resources for guidance in antibiotic dosing are shared with the audience.
Dr. Chambers, Professor of Medicine at the University of California, San Francisco, presents a state of the art lecture on current trends in the management of Staphylococcal bacteremia. Dr. Chambers begins by discussing risk factors leading to a poor outcome with Staphylococcus aureus bacteremia. He next discusses the role of Echocardiography (including 2D echo and TEE) in the diagnosis of endocarditis and when to use each modality in a given patient. Next, he contrasts the therapeutic management of both methicillin susceptible and methicillin resistant Staphylococcus aureus. Topics also discussed include the use of oral step down therapy in the treatment of endocarditis and bacteremia, the appropriate duration of treatment courses for bacteremia (both complicated and uncomplicated), and the use of combination antibiotic regimens for treating bacteremia infections.
Dr. Walter, Division Chief of the Department of Pediatric Allergy and Immunology at Johns Hopkins All Children’s Hospital, presents this basic review of Immunology. Dr. Walter begins by reviewing the basic classification of general immunodeficiency syndromes, and then covers the initial work-up for patients who are suspected as having an immune system deficiency. She then discusses signs and syndromes in specific patients that could suggest a primary immunodeficiency. Next, she discusses antibody deficiency syndromes and autoantibodies, She closes by discussing a specific immunodeficiency case with relevant details highlighted within the presentation.
Dr. Ju Hee Katzman, Assistant Professor of Infectious Diseases at the University of South Florida, presents an overview of the infectious diseases syndromes that can complicate the intrapartum or post-partum period. Dr. Katzman begins her presentation by discussing chorioamnionitis. She then reviews two post-partum syndromes, endometritis and refractory post-partum fever of undetermined origin. Next, Dr. Katzman discusses infections after perineal lacerations, including simple cases and more complicated ones involving deeper tissue involvement. Lastly, the treatment of UTIs in the peri-partum period is discussed, and Dr. Katzman closes by discussing post-abortal infections and the treatment of Group B Streptococcus agalactiae. Utilizing PollEverywhere, the material is presented in an interactive format.
Dr. Olga Klinkova, Infectious Diseases Practitioner at Moffitt Cancer Center and Research Institute in Tampa, FL, reviews the basics of Stem Cell Transplantation (SCT) from an Infectious Diseases perspective. She begins by reviewing the indications for SCT, and then discusses the basic types of SCT based upon donor/recipient characteristics (matched related, matched unrelated, etc.) She then differentiated the timelines between autologous and allogeneic transplants. Next, she discusses Graft versus Host disease and its consequences to the SCT patient. Dr. Klinkova then closes by covering prophylaxis strategies for stem cell transplant recipients. From a lecture recorded in October 2021.
Dr. Margarita Cancio, founder and Medical Director of the Infectious Diseases Associates of Tampa Bay, presents this talk on the infectious diseases management of transplant patients both before and after transplantation occurs. She begins by discussing the importance of a thorough pre-transplant evaluation, including a full history with regard to employment, travel, immunizations and other background history. She describes the laboratory evaluation of these patients, including specific screening studies. Next, infectious diseases history of the transplant donor is covered, as prior exposures to various infectious pathogens can affect the transplant recipient in many significant ways. Dr. Cancio then covers significant issues post transplantation, including the reactivation of certain infections such as the herpesviruses, hepatitis B and C, tuberculosis, and strongyloides infection. She then reviews the timing of certain infections after transplantation, with the highest risk period being directly after transplantation occurs. Lastly, infectious complications associated with specific immunosuppressove regimens and pre-transplant immunizations are reviewed.
Dr John Toney, Professor of Medicine and the Morsani College of Medicine and Chief of Epidemiology at the James A Haley Veterans Hospital shares new recommendations in the management of STDs and STIs. He begins by discussing recent epidemiologic trends in STDs in the US, including the increasing trend in new reported cases over the last 5 years. he then focuses on causes of urethritis/cervicitis, including Gonorrhea and Chlamydia. The updated treatment recommendations for GC and Chlamydia are also discussed. Next, Dr. Toney discusses Syphilis. He explains the rationale behind Treponemal and Non-treponemal tests and how they are used to diagnose the stage of syphilis that is present. Treatment options for early and late syphilis are also explored. Lastly, Dr. Toney discusses Herpes genitalis and Trichomoniasis.
Dr. Cannella, Assistant Professor at the University of South Florida Morsani College of Medicine, presents an introductory lecture on immune system function. He begins by discussing the first line body defenses such as the skin, mucous membranes, and lymphatic system. He then differentiates the innate versus the adaptive immune system. He then discusses other components of the immune system, including the complement pathway, antimicrobial peptides, PAMPS, DAMPS, phagocytosis, neutrophils, macrophages, dendritic cells, and NK (Natural Killer) cells. A second lecture is planned for later in the fall of 2021.
Dr. Sherbuk compares and contrasts the advantages and disadvantages of of intravenous versus oral antibiotic therapy regimens in the treatment of infections of bone and the heart in this new podcast. She begins by reviewing the history of osteomyelitis treatment, noting that IV therapy really predominated until the late 1980’s, then the first clinical studies of oral antibiotic therapy for osteo began. Dr. Sherbuk then focuses on the OVIVA trial. She concludes that although multiple RCTs demonstrate noninferiority, further research is needed on this treatment modality. The speaker next reviews PO Step-down therapy for endocarditis, including the POET trial. She concludes that PO step down therapy is an option for certain endocarditis patients, though several issues remain unclear including the length of the IV antibiotic lead-in, the preferred oral regimen, and the frequency of monitoring.