Dr. Jamie Morano, Director of the Infectious Diseases Telehealth and HIV Clinical Program at the James A Haley Veterans Hospital in Tampa, FL, reviews pre-exposure prophylaxis for HIV as well as the newer long acting injectable antiretroviral options. Dr. Morano begins by discussing the epidemiology of HIV infection in the Southeast U.S., one of the highest prevalence areas for HIV. She then reviews the recent research trials associated with cabotegravir-rilpiverine (Cabeneuva) and important information regarding its use. Next, she discusses specific administration details at her hospital as well as injection techniques. Lastly, Dr. Morano covers PrEP indications and prescribing tips and how telehealth care can enhance care in PrEP, nPEP, HIV longitudinal care, STD treatment, sexual health, and general infectious diseases care.
Managing Beta-Lactam Allergies
Dr. Tiffany Ward, Infectious Diseases Pharmacist at the James Haley VA hospital in Tampa, FL, begins her presentation by reviewing the impact of beta-lactam allergies on individual patients and the healthcare system. She then discusses the classification system for the different types of hypersensitivity reactions. Next, Dr. Ward discusses the various dermatologic manifestations of an acute drug allergy. Dr. Ward then mentions the use of cephalosporins in patients with penicillin allergies. She goes on to explain how beta-lactam allergy testing is performed. Lastly, she relates the importance of updating antibiotic allergy information in the medical chart for effective anti-infective management and care.
Sexually Transmitted Infections Update 2022-23
Dr. John Toney, Professor of Medicine at the USF Morsani College of Medicine, presents this STI treatment refresher updated for 2022-2023. Dr. Toney begins by reviewing the new changes to the latest 2021 STI guidelines (updated from 2015). He next discusses Chlamydia and Neisseria, Chancroid and LGV. Next, he discusses syphilis. Topics discussed related to syphilis includes differentiating primary, secondary, and latent disease, diagnostic testing and treatment. Dr. Toney closes by discussing genital Herpes and Trichomoniasis.
Dr. Shylah Moore-Pardo, Assistant Professor of Medicine at the Morsani College of Medicine, presents a review of parasitic diseases of the skin and soft tissues. Clinical syndromes discussed include pediculosis (head and body/pubic lice), scabies, bedbugs, myiasis, tungiasis, and cutaneous larva migrans. Syndromes with a geographic preference are associated with their locality of origin. The presentation is conducted in a case-based format, aiding in learning of the material.
Hepatitis A, B, and C Clinical Overview
Dr Todd Wills, Professor of Medicine at the University of South Florida College of Medicine, presents an overview of the management of viral hepatitis syndromes. Dr. Wills first discusses Hepatitis A, including its case definition, epidemiology, high risk groups, and vaccine target population. Next, Hepatitis B is introduced. Dr. Wills explains how to interpret serology test results, and specifies the high risk populations that require treatment. Next the speaker discusses the various antiviral agents available to treat patients who have Hepatitis B infection. Lastly, Hepatitis C is discussed, including the disease’s prevalence, treatment options, the importance of genotyping, and post treatment monitoring.
Dimorphic Endemic Fungal Infections
Dr. John Greene, Chief of Infectious Diseases at the Moffitt Cancer Center and Research Institute, reviews the epidemiology, clinical characteristics, and disease manifestations of several endemic fungal mycoses. Among the fungal organisms discussed includes, Histoplasmosis, Blastomycosis, Coccidioidomycosis, Paracoccidioidomycosis and Cryptococcosis.
Note: We apologize for some of the technical difficulties present in this presentation, including some obscured slides and the Zoom overlay panel along the top of the presentation window.
Mechanisms of Gram Negative Resistance
Austin Morrison, Antimicrobial Stewardship Pharmacist at Moffitt Cancer Center and Research Institute, presents a broad overview of gram negative resistance. Topics discussed include the basic mechanisms of resistance, the classification scheme for beta-lactamases, as well as more specific information regarding specific beta-lactamse groups. First discussed are the the Class C (Amp C) beta-lactamases, followed by the Carbapenem-resistant Enterobacterales (CRE) organisms, and then difficult to treat Pseudomonas aeruginosa (DTR). Several case studies are also presented to help understand the clinical effects and available treatment options for these resistance mechanisms.
Selected Gram Positive Bacteria of Clinical Significance
Dr. Jacqueline Sherbuk, Assistant Professor at the Morsani College of Medicine Division of Infectious Diseases, presents a review on several important classes of clinically significant gram-positive bacteria. Dr. Sherbuk begins by discussing Staphylococcus aureus, MRSA, and Coagulase negative Staphylococci and some of the clinical syndromes they can cause. Next, Dr. Sherbuk introduces Streptococcus pneumonia and the syndrome of invasive pneumococcal disease. Then, Group A strep pyogenes, the viridans streptococci, and the variant streptococci are related. Also presented are Enterococcus faecalis and vancomycin resistant enterococcus faecium. Lastly, Dr. Sherbuk references Corynebacterium spp., Listeria, Bacillus, and Erysipelothirx spp.
The Spirochetes: Leptospirosis and Relapsing Fever
Dr. Richard L. Oehler, Professor of Medicine at the Division of Infectious Diseases, Morsani College of Medicine, reviews two important clinical syndromes caused by Spirochetes. Dr Oehler begins by presenting an actual clinical case of Leptospirosis in a returning traveller from the Caribbean. He then discusses the epidemiology of Leptospira, a widespread zoonotic pathogen that favors temperate and topical climates worldwide.He then relates the life cycle, means of transmission, microbiology, clinical manifestations, and most relevant diagnostic studies. He concludes the leptospirosis section by discussing treatment and prevention . The second case he discusses is a febrile illness in a returning traveler from Jordan. Dr. Oehler goes on to discuss the epidemiology and classification system for relapsing fever (RF), and its broad categorization into tick-borne (endemic) and louse-borne (epidemic) forms. He further describes the characteristics of the soft-shelled Ornithodoros ticks and the Human Body Louse. He then relates the clinical manifestations, diagnostic criteria, and treatment options for each form of RF. Lastly, Dr, Oehler breaks down treatment and prevention strategies for each form of relapsing fever.
Overview of Osteomyelitis
Dr. Margarita Cancio, Medical Director of the Infectious Diseases Associates of Tampa Bay, draws on her decades of experience in treating orthopedic infectious to present this overview of the management of infections of bone and joints. She begins by discussing hematogenous osteomyelitis in both children and adults, and differentiates its presentation, microbiology, surgical management, and therapy. Next, she covers contiguous osteo, relating its pathophysiology, diagnosis, and the surgical classification systems associated with it. She then differentiates between bone infections related to open fractures and closed-type fractures. Lastly, she covers prosthetic joint infections and how to interpret histopathological bone protocols.