Dr. Mel O’Neal, Infectious Diseases pharmacist at Tampa General Hospital, presents part 2 of her series on Gram Negative Resistance, focusing on therapeutics for treatment of these resistant pathogens. Dr. O’Neal begins by identifying the main resistance mechanisms, including membrane porins, efflux pumps, drug binding site mutations, and degrading enzymes (e.g., beta-lactamases.) She then systematically covers the major agents used for treating resistant gram negative rods, including the newer beta-lactamase inhibitors, cefiderocol, and third-generation tetracyclines. Cases are also presented to emphasize the topics covered.
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