Mechanisms of Gram Negative Resistance

Austin Morrison, Pharm.D
Thursday, January 5, 2023
Category: Antimicrobial Resistance Mechanisms, Antimicrobial Stewardship, Bacterial Infections, Pharmacotherapy

Austin Morrison, Antimicrobial Stewardship Pharmacist at Moffitt Cancer Center and Research Institute, presents a broad overview of gram negative resistance. Topics discussed include the basic mechanisms of resistance, the classification scheme for beta-lactamases, as well as more specific information regarding specific beta-lactamse groups. First discussed are the the Class C (Amp C) beta-lactamases, followed by the Carbapenem-resistant Enterobacterales (CRE) organisms, and then difficult to treat Pseudomonas aeruginosa (DTR). Several case studies are also presented to help understand the clinical effects and available treatment options for these resistance mechanisms.

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