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Essentials of Antibiotic Dosing: Pharmacokinetics and Pharmacodynamics

By Austin Morrison, Pharm.D

August 23rd, 2022

Austin Morrison, Infectious Diseases and Antimicrobial Stewardship Clinical Pharmacist at the Moffitt Cancer Center and Research Institute, presents a talk on the pharmacokinetic and pharmacodynamic principles associated with the optimal dosing of antimicrobial agents. Dr. Morrison begins by defining basic antimicrobial concepts, including absorption, distribution, metabolism, and excretion. He then compares and contrasts concentration-dependent versus time-dependent killing as it applies to different antimicrobial classes. Dr. Morrison then specifically singles out beta-lactams and time-dependent killing and the benefits of extended dosing strategies. He also discusses the significance of the AUC/MIC curve. Lastly, Dr. Morrison concludes by discussing antibiotic dosing in renal insufficiency and the ideal strategies for this group of patients.

HIV/AIDS: Optimism and New Directions for Ending the Epidemic

By Jamie Morano, MD

August 22nd, 2022

Dr. Jamie Morano, Associate Professor at the USF Morani College of Medicine, presents an overview of HIV/AIDS care in 2022. Dr. Morano begins by reviewing HIV epidemiology, including national regions of high HIV prevalence. She then discusses the “Test and Treat” approach to management. Antiretroviral treatment updates are presented, included the use of TAF and the new availability of longer acting injectable agents. HIV testing issues are also discussed, including testing barriers and HIV-related stigma. The concept of Undetectable=Untransmissable is also discussed. Lastly, Dr. Morano reviews PREP (preexposure prophylaxis) and nPEP (non-Occupational Post exposure Prophylaxis) for HIV.

Basic Immunology

By Anthony Cannella, MD

August 18th, 2022

Dr. Anthony Cannella, Infectious Diseases Clinician and Associate Professor with the Division of Infectious Diseases at the Morsani College of Medicine, presents a primer on basic immunology for clinicians. Dr. Cannella begins by drawing a distinction between innate and adaptive immunity. He then discusses the complement cascade, antimicrobial peptides, PAMPS, and DAMPS. Next, Dr. Cannella reviews individual components of the immune system, including neutrophils, eosinophils, macrophages, dendritic cells, and natural killer cells. Lastly, the remaining components of the immune system are covered, including B cells, immunoglobulins, and T cells and their function.

ID Management of Patients with Hematologic Malignancies and Stem Cell Transplants

By Olga Klinkova and Aliyah Baluch

August 4th, 2022

Dr. Olga Klinkova covers essential information regarding the management of infectious complications of hematologic malignancies. Topics covered include the initial evaluation of patients, neutropenic fever, neutropenic enterocolitis, and antimicrobial prophylaxis. Next, Dr. Baluch discusses ID management of stem cell transplants, CAR-T therapy, and when it is necessary to administer antimicrobial prophylaxis in these patients. The talks are from an Infectious Diseases Bootcamp for ID Fellows recorded in August 2022.

Infectious Diseases Emergencies

By Guy Handley, MD

August 4th, 2022

Dr. Guy Handley, Assistant Professor with the Division of Infectious Diseases at the Morsani College of Medicine, presents his talk on infectious diseases emergencies. He discusses a variety of different syndromes, including bacterial meningitis, neutropenic fever, bacteremia, malaria, and viral hemorrhagic fevers. The information is presented in a Q&A format. This talk is Part of the “Infectious Diseases Bootcamp” series for USF infectious Diseases fellows presented in August, 2022.

Infectious Complications of the Primary Immunodeficiencies

By Tuhina Cornelius, MD

July 26th, 2022

Dr. Tuhina Cornelius, senior infectious diseases fellow at the University of South Florida College of Medicine, reviews the primary immunodeficiencies in this podcast presentation. The speaker begins by presenting the basics regarding the differences between cellular and humoral immunity. She then discusses specific B cell and T cell related immune deficits. Dr. Cornelius then goes on to describe disorders of phagocytosis, motility, complement, and other miscellaneous syndromes. Lastly, the management of these disorders is reviewed.

Tuberculosis: The Great Imitator

By Suhel Sabunwala, MD

July 15th, 2022

Dr. Suhel Sabunwala, Senior Infectious Diseases fellow at the University of South Florida College of Medicine, presents an update on Tuberculosis, a legacy disease of mankind rich in history and very much still highly prevalent in the modern world. Dr. Sabunwala begins by discussing the history of tuberculosis. He then transitions to the current status of TB disease and its impact in the US and across the globe. He further discusses how TB and COVID-19 have interacted during the pandemic. Lastly, the speaker discusses updates in treatment and global targets for eradication.

Genitourinary Tract Infections: Update for 2022

By John Toney, MD, FIDSA

July 5th, 2022

Dr. John Toney, Professor of Medicine at the University of South Florida Division of Infectious Diseases, presents an update on Genitourinary tract infections. He begins the presentation by discussing the many manifestations of UTIs, from asymptomatic bacteriuria to cystitis to pyelonephritis. He then differentiates acute uncomplicated and acute complicated cystitis. Next, he discusses acute pyelonephritis, its management and treatment options. More information on the assessment of asymptomatic bacteriuria is also presented. Next, Dr. Toney transitions to discussing updates in the the management and treatment of STI’s including Gonorrhea, Chlamydia, and Syphilis with an emphasis on the recent guidelines updates.

Update on CMV and Treatment Options for 2022

By Aliyah Baluch, MD, Msc

May 19th, 2022

Dr. Aliyah Baluch, Program Director of the Infectious Diseases Transplant Program at the Moffitt Cancer Center and Research Institute, presents an update on CMV infections in the Immunocompromised host. She begins by discussing the basics of allogeneic stem cell transplantation, including pre-transplant screening and what differentiates a “high risk transplant.” She then provides some background information on Cytomegalovirus, including its clinical manifestations in susceptible patients. Next, Dr. Baluch conveys the phases of infection in stem cell transplant, and identifies the high risk period for CMV disease to typically occur. She then discusses CMV diagnosis, antiviral therapies, and CMV prophylaxis strategies. Dr. Baluch closes by discussing CMV drug resistance as well as several information resources useful in the management of CMV-infected patients.

Neglected Tropical Diseases: Part II

By Ana Sikora, MD

May 12th, 2022

Dr. Ana Sikora, Infectious Diseases Fellow at the University of South Florida Division of Infectious Diseases, presents a review of lesser known tropical infectious diseases syndromes. Dr. Sikora begins by discussing the epidemiology of tropical diseases, and then prioritizes the most important ones based upon WHO categorization. Syndromes discussed includes Drucunculiasis, lymphatic filariasis, Onchocerciasis, soil transmitted helminths, and Schistosomiasis. Lastly, the process by which international organizations such as the WHO coordinate efforts to control or eradicate these syndromes is briefly discussed.