The Great Debate: Sensitive versus Susceptible

Amanda Mercurio Pharmd
Amanda Mercurio, PharmD
Tuesday, August 11, 2020
Category: Antimicrobial Resistance Mechanisms, Antimicrobial Stewardship, Bacterial Infections, Pharmacotherapy

Dr. Mercurio reviews antimicrobial susceptibility testing methods and explains how this data reported with culture results can be best used to make informed antibiotic treatment decisions. Dr. Mercurio begins by discussing the difference between MIC and MBC, and the misconceptions about MIC values for different antibiotic agents. Next, she reviews recent changes in the susceptibility breakpoints for several bacterial organisms, including Enterococcus spp., Staphylococcus aureus, Enterobacteriaceae, and Pseudomonas. Lastly, she reviews the resistance issues with the “SPACE/SPICE” bacteria as well as inducible clindamycin resistance, and closes with comments on heteroresistance issues in bacterial populations.

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