Dr. Jamie Morano speaks about the long term outcomes in HIV-infected patients. She reviews immune reconstitution, the factors that lead to ART success, management of aging patients with longer lifespans, and implications for the future. Immune Reconstitution involves the expected recovery of the immune system when ART is initiated, while an unmodulated immune response characterized by worsening opportunistic infections is called IRIS. She also addresses HIV latency in other organ systems, HIV non-progressors, IRIS morbidity and mortality, and generational differences in HIV treatment outcomes. She touches on pre-exposure prophylaxis for high-risk individuals – men who have sex with men and intravenous drug users. Finally, she covers future infectious disease concerns for HIV patients, including MERS-CoV and reemerging vaccine preventable infections.
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