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Dimorphic Endemic Fungal Infections

By John Greene, MD

January 12th, 2023

Dr. John Greene, Chief of Infectious Diseases at the Moffitt Cancer Center and Research Institute, reviews the epidemiology, clinical characteristics, and disease manifestations of several endemic fungal mycoses. Among the fungal organisms discussed includes, Histoplasmosis, Blastomycosis, Coccidioidomycosis, Paracoccidioidomycosis and Cryptococcosis.

 

Note: We apologize for some of the technical difficulties present in this presentation, including some obscured slides and the Zoom overlay panel along the top of the presentation window.

Mechanisms of Gram Negative Resistance

By Austin Morrison, Pharm.D

January 5th, 2023

Austin Morrison, Antimicrobial Stewardship Pharmacist at Moffitt Cancer Center and Research Institute, presents a broad overview of gram negative resistance. Topics discussed include the basic mechanisms of resistance, the classification scheme for beta-lactamases, as well as more specific information regarding specific beta-lactamse groups. First discussed are the the Class C (Amp C) beta-lactamases, followed by the Carbapenem-resistant Enterobacterales (CRE) organisms, and then difficult to treat Pseudomonas aeruginosa (DTR). Several case studies are also presented to help understand the clinical effects and available treatment options for these resistance mechanisms.

Selected Gram Positive Bacteria of Clinical Significance

By Jacqueline Sherbuk, MD

November 21st, 2022

Dr. Jacqueline Sherbuk, Assistant Professor at the Morsani College of Medicine Division of Infectious Diseases, presents a review on several important classes of clinically significant gram-positive bacteria. Dr. Sherbuk begins by discussing Staphylococcus aureus, MRSA, and Coagulase negative Staphylococci and some of the clinical syndromes they can cause. Next, Dr. Sherbuk introduces Streptococcus pneumonia and the syndrome of invasive pneumococcal disease. Then, Group A strep pyogenes, the viridans streptococci, and the variant streptococci are related. Also presented are Enterococcus faecalis and vancomycin resistant enterococcus faecium. Lastly, Dr. Sherbuk references Corynebacterium spp., Listeria, Bacillus, and Erysipelothirx spp.

The Spirochetes: Leptospirosis and Relapsing Fever

By Richard L. Oehler, MD

November 14th, 2022

Dr. Richard L. Oehler, Professor of Medicine at the Division of Infectious Diseases, Morsani College of Medicine, reviews two important clinical syndromes caused by Spirochetes. Dr Oehler begins by presenting an actual clinical case of Leptospirosis in a returning traveller from the Caribbean. He then discusses the epidemiology of Leptospira, a widespread zoonotic pathogen that favors temperate and topical climates worldwide.He then relates the life cycle, means of transmission, microbiology, clinical manifestations, and most relevant diagnostic studies. He concludes the leptospirosis section by discussing treatment and prevention . The second case he discusses is a febrile illness in a returning traveler from Jordan. Dr. Oehler goes on to discuss the epidemiology and classification system for relapsing fever (RF), and its broad categorization into tick-borne (endemic) and louse-borne (epidemic) forms. He further describes the characteristics of the soft-shelled Ornithodoros ticks and the Human Body Louse. He then relates the clinical manifestations, diagnostic criteria, and treatment options for each form of RF. Lastly, Dr, Oehler breaks down treatment and prevention strategies for each form of relapsing fever.

Overview of Osteomyelitis

By Margarita Cancio, MD, FACP

November 10th, 2022

Dr. Margarita Cancio, Medical Director of the Infectious Diseases Associates of Tampa Bay, draws on her decades of experience in treating orthopedic infectious to present this overview of the management of infections of bone and joints. She begins by discussing hematogenous osteomyelitis in both children and adults, and differentiates its presentation, microbiology, surgical management, and therapy. Next, she covers contiguous osteo, relating its pathophysiology, diagnosis, and the surgical classification systems associated with it. She then differentiates between bone infections related to open fractures and closed-type fractures. Lastly, she covers prosthetic joint infections and how to interpret histopathological bone protocols.

Overview of Respiratory Viruses

By Ana Velez, MD

October 31st, 2022

Dr. Ana Velez, Associate Professor with the University of South Florida Division of Infectious Diseases, presents an overview of clinically significant respiratory viruses. Dr. Velez mentions several agents including parainfluenza, RSV, Human Metapneumovirus, Influenza A and B, Rhinoviruses, and the non-COVID-19 Coronaviruses. The speaker touches on the seasonality of respiratory viruses, reviews clinical manifestations, epidemiology, prevention and treatment options.

Arboviruses and Zoonotic Infections

By Jacqueline Sherbuk, MD

October 18th, 2022

Dr. Jackie Sherbuk, Assistant Professor at the Division of Infectious Diseases and International Medicine at the USF Morsani College of Medicine presents this Podcast on Viral Zoonotic and Arboviral infections. Medical syndromes discussed includes Rabies, Orf (Ecthyma contagiosum), Herpes B Virus, Alphavirus, Chikungunya, Dengue fever, Yellow fever, West Nile Virus, Japanese Encephalitis, Tick-borne Encephalitis, Hantavirus, California Encephalitis, And Lymphocytic Choriomeningitis virus. Board review type questions are also presented to aid in integrating the information presented in the talk

Guidelines on the Management of C. difficile Infection in Adults

By Cynthia Mayer, D.O., FACOI

October 13th, 2022

Dr. Cynthia Mayer, Infectious Diseases Clinician at the Infectious Diseases Associates of Tampa Bay, presents a review of Clostridium difficile infection. Dr. Mayer reviews the proposed etiologies of C difficile infection. She then covers the clinical presentation of C difficile infection and reviews the relevant examination criteria. Next, Dr. Mayer summarizes the treatment and management options for Clostridium difficile based upon the specific etiology. Lastly, the speaker discusses appropriate infection control management strategies.

Endocarditis

By Margarita Cancio, MD, FACP

October 6th, 2022

Dr. Margarita Cancio, Medical Director of the Infectious Diseases Associates of Tampa Bay, presents a talk on the assessment and management of infectious endocarditis. Dr. Cancio begins by reviewing the epidemiology of endocarditis. She then discusses the the microbiology of endocarditis pathogens in both native valve and prosthetic valve disease. The clinical manifestations of endocarditis are next discussed. Following this, Dr. Cancio discusses treatment options. Other issues discussed include culture negative disease, surgical management, CIED infections, cardiac imaging, and antimicrobial prophylaxis.

Sepsis: The Saga Continues

By John Toney, MD, FIDSA

October 6th, 2022

Dr. John Toney, Professor of Medicine at the USF Division of Infectious Diseases, presents an update on Sepsis. Topics presented included the recognition of sepsis and septic shock, the principles of resuscitation, the treatment of infection, the importance of reducing secondary infection rates, and controlling hyperglycemia. Lastly, specific treatments for severe sepsis are also discussed.